May 1, 1981Acta Physiologica Scandinavica

Interstitial fluid volume, colloid osmotic and hydrostatic pressures in rat skeletal muscle. Effect of venous stasis and muscle activity

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Population

Rats divided into three groups: Group I, Group II, and Group III

Comparison

24 h caval/iliac venous obstruction vs Control state without venous obstruction

Design

Preclinical

Follow-up

24 hours

Authors

RRRolf K. ReedUppsala University

Discussion

Member takes

Implication

Muscle activity and protein washout may prevent edema in venous stasis; leaves open translation to human disease.

Structured PICO

Population

Rats divided into three groups: Group I (intact innervation, unrestricted motor activity), Group II (sympathectomized, unrestricted), and Group III (motoric and sympathetic denervation + immobilization of the hindlimbs)

Intervention

24 h caval/iliac venous obstruction

Comparator

Control state without venous obstruction

Outcome

Interstitial fluid volume (IFV), hydrostatic pressure (Pi), and colloid osmotic pressure (COPi) in hindlimb skeletal musclesurrogate

Normal muscle activity, along with dilution and washout of interstitial proteins, constitutes the primary mechanism preventing edema in skeletal muscle during venous stasis.

Cite This Study

Rolf K. Reed (1981) studied this question.

synapsesocial.com/papers/6a764af259770ea2c0bcb903 https://doi.org/10.1111/j.1748-1716.1981.tb06776.x

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