I want a new drug dose: External on-demand laser triggering is used in a drug-delivery concept, with on/off ratios in excess of 1000/1. The switching mechanism involves the glass transition of hydrophobic polymers with a large change in diffusivity. Formation of a glassy surface layer of the implant in the off state plays a key role, resulting in negligible off-release. (Picture: data points indicate ibuprofen concentration).
No takes yet. Share an insight, caveat, or question.
Keurentjes et al. (2009) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: