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April 14, 2005HeartOpen Access

Late reopening of an occluded infarct related artery improves left ventricular function and long term clinical outcome

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Why the study?

Does successful late PTCA of a chronically occluded infarct-related artery improve left ventricular function and reduce major adverse cardiac events in patients with a previous myocardial infarction?

Population

65 patients with a chronically occluded infarct related artery who underwent percutaneous transluminal…

Comparison

Successful late percutaneous transluminal… vs Unsuccessful or partially successful late PTCA…

Design

Cohort

Follow-up

6 months for echocardiography, 3 years for clinical outcomes

Authors

FPFederico PiscioneGGGennaro GalassoGLGiuseppe De Luca

Discussion

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Member takes

Overview

Supports TIMI 3 flow after late PTCA in chronic occlusion for better LVEF and outcomes; hypothesis-generating and requires RCTs before practice change.

Structured PICO

Does successful late PTCA of a chronically occluded infarct-related artery improve left ventricular function and reduce major adverse cardiac events in patients with a previous myocardial infarction?

P
Population
65 patients with a chronically occluded infarct related artery who underwent percutaneous transluminal coronary angioplasty (PTCA) a mean 6.0 months after a previous myocardial infarction
I
Intervention
Successful late percutaneous transluminal coronary angioplasty (PTCA) achieving TIMI grade 3 flow (n=35)
C
Comparator
Unsuccessful or partially successful late PTCA achieving TIMI grade 0-2 flow (n=30)
O
Outcome
Major adverse cardiac events (MACE) at 3 years follow-upcomposite

Achieving TIMI 3 flow during late PTCA of a chronically occluded infarct-related artery is associated with improved left ventricular function and better long-term clinical outcomes.

Cite This Study

Piscione et al. (2005) studied this question.

synapsesocial.com/papers/6a76536d5db9de976abcc2e7https://doi.org/10.1136/hrt.2004.041152
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A randomized trial of late reperfusion therapy for acute myocardial infarction. Thrombolysis and Angioplasty in Myocardial Infarction-6 Study Group.1992 · 209 citations
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  3. 3Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase. Clinical findings through hospital discharge.1987 · 2,255 citations
  4. 4<b>Predictors of Clinical Outcome Following NIR Stent Implantation for Coronary Artery Disease:</b> Analysis of the Results of the First International New Intravascular Rigid‐Flex Endovascular Stent Study (FINESS Trial)2002 · 5 citations
  5. 5Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernation.1991 · 436 citations