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March 1, 1995Circulation Research

Mechanism of Impaired Myocardial Function During Progressive Coronary Stenosis in Conscious Pigs

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Population

Conscious minipigs instrumented with a coronary ameroid constrictor and hydraulic occluder, regional wall…

Design

Preclinical

Follow-up

20 +/- 3 days

Authors

YSYou‐Tang ShenUniversity of PennsylvaniaSVStephen F. VatnerHeart Failure & Transplant

Discussion

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Implication

Stunning, not resting flow deficit, drives dysfunction in this porcine model; leaves open relevance to human chronic coronary syndromes.

Key Points

  • To determine whether impaired contractile function during progressive coronary artery stenosis reflects chronic myocardial hibernation or cumulative myocardial stunning.
  • Instrumented conscious minipigs (n=7) with ameroid constrictors, hydraulic occluders, wall thickness crystals, and pressure catheters to monitor hemodynamic function over time.
  • Assessed systolic wall thickening distal to the constriction and transmural myocardial blood flow at baseline, during complete occlusion, and during spontaneous activity.
  • Systolic wall thickening distal to the ameroid decreased by a maximum of 56 ± 6% at 20 ± 3 days without alterations in baseline endocardial (0.92 ± 0.10 mL/min/g) or epicardial (0.85 ± 0.12 mL/min/g) blood flow.
  • Brief coronary occlusions at day 20 reduced wall thickening (-83 ± 12%) and blood flow without causing gross myocardial necrosis on tissue pathology (n=4).
  • Acute, transient drops in wall thickening occurred after spontaneous increases in heart rate and left ventricular dP/dt, exhibiting delayed functional recovery.

Structured PICO

P
Population
Conscious minipigs instrumented with a coronary ameroid constrictor and hydraulic occluder, regional wall thickness crystals, a left ventricular (LV) pressure gauge, and aortic and left atrial catheters (n=7 for wall thickening measurements, n=4 for pathology).
I
Intervention
Progressive coronary artery stenosis induced by ameroid constriction
O
Outcome
Myocardial contractile function (systolic wall thickening) and myocardial blood flowsurrogate

Impaired myocardial function during progressive coronary stenosis in a porcine model reflects cumulative myocardial stunning rather than a primary deficit in resting coronary blood flow (hibernating myocardium).

Cite This Study

Shen et al. (1995) studied this question.

synapsesocial.com/papers/6a76536e5db9de976abcc2e9https://doi.org/10.1161/01.res.76.3.479
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An animal model of chronic coronary stenosis resulting in hibernating myocardium1992 · 74 citations
  2. 2Development of coronary collateral circulation in left circumflex Ameroid-occluded swine myocardium1987 · 125 citations
  3. 3Functional evaluation of coronary collateral development in conscious dogs1981 · 44 citations
  4. 4Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.1975 · 1,014 citations
  5. 5The Development of Collateral Circulation in the Pig and Dog Heart2008 · 123 citations