Engineered myosin motors with optimized stability and regulation offer opportunities for controlling movement in nano- to microscale biohybrid devices.
Engineered myosins may enable tunable biohybrid actuators; leaves open translation to cardiovascular devices pending in vivo validation.
A long life with controlled movement: Engineered protein nanomachines with defined and adjustable functional features offer opportunities for controlling movement on nano- to microscale biohybrid devices. Myosin motors (the picture shows a dimeric motor) have now been constructed with optimized properties with regard to stability and regulation, including switchable processivity and tight control of the velocity of movement.
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Amrute‐Nayak et al. (2009) studied this question.
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