Why the study?
Do plasma levels of NT-proBNP and cTnT predict prognosis in hospitalized patients with sepsis?
Do plasma levels of NT-proBNP and cTnT predict prognosis in hospitalized patients with sepsis?
Elevated plasma levels of NT-proBNP and cTnT are associated with higher mortality in patients with sepsis and may serve as prognostic biomarkers.
May inform sepsis risk stratification; leaves open need for larger prospective validation before practice change.
Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in patients with sepsis and to analyze their prognostic significance. A total of 38 hospitalized patients with sepsis were included in the present study. The patients were divided into the survival and death groups, based on their prognosis. The plasma levels of NT-proBNP and cTnT for the two groups were measured for all the patients on the 1st, 3rd and 7th day of admission. The plasma levels of NT-proBNP and cTnT between the two groups were compared and their association with prognosis were analyzed. The plasma levels of NT-proBNP and cTnT in the death group were significantly higher than those in the survival group (P<0.05). Additionally, a positive assocciation of the plasma levels of NT-proBNP and cTnT was identified (P<0.05). In conclusion, the plasma levels of NT-proBNP and cTnT may be used as routine clinical biomarkers to assess the prognosis of patients with sepsis.
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Wang et al. (2015) studied this question.
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