Why the study?
QTc prolongation during targeted temperature management post cardiac arrest is a known effect of hypothermia, but its significance is unclear, with limited cases reporting QTc intervals >700 milliseconds.
Severe QTc prolongation (>700 ms) can occur during targeted temperature management post-cardiac arrest, highlighting the need for guidelines on EKG monitoring and TTM termination thresholds.
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Extreme QTc prolongation during TTM may occur without arrhythmia; leaves open need for larger studies on extreme cases.
BACKGROUND QTc prolongation during targeted temperature management (TTM) post cardiac arrest is a known effect of hypothermia, but its significance is unclear. Several studies suggest that temporary prolongation during TTM is not prognostic and does not potentiate fatal arrhythmias; however, there are limited cases of patients presenting with QTc intervals >700 milliseconds. CASE REPORT We describe a case in which a 57-year-old woman with diabetes, hypertension, and atrial fibrillation presented with concern for stroke. The hospital course was complicated by cardiac arrest requiring TTM, which was stopped early due to significant QTc prolongation of 746 milliseconds. CONCLUSIONS TTM is beneficial post resuscitation for good neurological outcomes, but it also has known adverse cardiac effects such as QTc prolongation. The significance of QTc prolongation during TTM is unclear as several studies have shown no increased incidence of malignant arrhythmias. One case report in the literature describes the incidence of torsades de pointes due to QTc prolongation during TTM. Further study and guidelines regarding electrocardiogram monitoring are needed to determine the importance of QTc prolongation during TTM.
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Purewal et al. (2020) studied this question.
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