Why the study?
Are cerebrospinal fluid levels of renin-angiotensin system components associated with Alzheimer's disease pathology?
Are cerebrospinal fluid levels of renin-angiotensin system components associated with Alzheimer's disease pathology?
Decreased CSF levels of ACE in Alzheimer's disease patients correlate with Aβ42 burden, suggesting an association between ACE and Aβ pathology.
This study was designed to determine whether the levels of renin-angiotensin system (RAS) components are associated with Alzheimer's disease (AD) pathology. Cerebrospinal fluid levels of Angiotensin (Ang) II, Ang-(1-7), angiotensin-converting enzyme (ACE), ACE2, Amyloid-β (Aβ)40, Aβ42, total tau (hTau), and phospho-tau (pTau) were measured in 18 patients with AD and 10 controls. Patients with AD presented decreased levels of ACE when compared with controls. We found a significant positive correlation between ACE and Aβ42 levels among patients. Our results strengthen the hypothesis that ACE is associated with Aβ pathology in AD.
No takes yet. Share an insight, caveat, or question.
Rocha et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: