Key result
ACE-1 activity was significantly increased in Alzheimer's disease brains compared to controls (P<0.001) and correlated directly with parenchymal amyloid-beta load (P=0.05).
Case-Control (n=172)
p-value: p=<0.001
ACE-1 activity is increased in Alzheimer's disease brains and correlates with amyloid-beta load, with perivascular accumulation in severe cerebral amyloid angiopathy.
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ACE-1 elevation in AD should not change practice; leaves open causal role in amyloid accumulation.
Miners et al. (2007) conducted a case-control in Alzheimer's disease and cerebral amyloid angiopathy (n=172). Alzheimer's disease (exposure) vs. Control brains was evaluated on ACE-1 activity in the frontal cortex (p=<0.001). ACE-1 activity was significantly increased in Alzheimer's disease brains compared to controls (P<0.001) and correlated directly with parenchymal amyloid-beta load (P=0.05).
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