A novel tandem aziridination/rearrangement reaction of allylic alcohols has been discovered, in which the significant accelerating effect of silica gel has been identified. On the basis of this methodology, an efficient and highly stereoselective approach to various 2-quaternary Mannich bases has been put in place, readily providing an alternative route to the conventional vicinal amino-functionalization of alkenes.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2008) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: