Lewis basic, metal-free pyridyloxazolines catalyze the reduction of prochiral aromatic ketones and ketimines with Cl3SiH in good enantioselectivity (up to 94 % ee). Arene–arene interactions between the substrate and the catalyst are likely to play a role in the enantiodifferentiation process.
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Malkov et al. (2006) studied this question.
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