Synthetic Models of the Active Site of Cytochrome P‐450. 1st Communication. The Synthesis of a Doubly‐Bridged Iron(II)‐Porphyrin Carrying a Tightly Bound Thiolate Ligand

The doubly‐bridged iron(II)‐tetraphenylporphyrin derivative 6 , carrying a sterically fixed S − ligand in the ‘proximal’ position and the substrate at the ‘distal’ site, was synthesised as an enzyme model for cytochrome P‐450. Compound 36 , the CO complex of 6 , displays a split Soret band (403 and 457 nm) similar to the native cytochrome P‐450.