October 1, 2025Advanced Biomedical ResearchOpen Access

Aerobic Exercise Modulates Lipo-Toxicity Genes Expression in Cardiac Tissue of Obese Rats Induced with High-Fat and Fructose Diet

View Full Paper

Ask AI

Bookmark

Why the study?

Obesity contributes to cardiovascular diseases, prompting investigation into how aerobic exercise impacts cardiac tissue lipo-toxicity gene expression in diet-induced obese male rats.

Does aerobic exercise modulate lipo-toxicity gene expression in the cardiac tissue of obese rats?

Population

Twenty-four male Wistar rats

Comparison

Aerobic exercise vs high-fat and fructose diet alone vs standard diet

Design

Randomized animal study

Authors

FKFatemeh Khadem MSMarina ShariatiIslamic Azad University, Ahvaz Branch HKHeshmat Kavehzadeh

Discussion

Member takes

Implication

No immediate clinical implications for obese patients; leaves open translation of gene modulation to human cardiovascular outcomes.

Structured PICO

Does aerobic exercise modulate lipo-toxicity gene expression in the cardiac tissue of obese rats?

Population

24 male Wistar rats, 8 weeks old, weighing approximately 300 ± 11.3 g, subjected to a high-fat (60%) and high-fructose (25%) diet to induce obesity.

Intervention

Continuous aerobic exercise on a treadmill (average intensity of 15 m/min for 30 min, 5 times a week) from the 8th week to the 16th week, while continuing a 60% fat and 25% fructose diet.

Comparator

Obese control group (maintained on 60% fat and 25% fructose diet without exercise) and healthy control group (maintained on a standard diet).

Outcome

Expression levels of lipo-toxicity genes (PPARα, PGC1-α, PDK4, and mCPT1) in cardiac tissue measured by real-time PCR.surrogate

Aerobic exercise modulates lipo-toxicity gene expression and reduces lipid deposition in the cardiac tissue of obese rats, suggesting potential metabolic benefits for obesity-related cardiovascular dysfunction.

Cite This Study

Khadem et al. (2025) studied this question.

synapsesocial.com/papers/6a765db1a2903f5314475447 https://doi.org/10.4103/abr.abr_201_24

View Full Paper

Ask AI

Bookmark

Aerobic Exercise Modulates Lipo-Toxicity Genes Expression in Cardiac Tissue of Obese Rats Induced with High-Fat and Fructose Diet

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Aerobic Exercise Modulates Lipo-Toxicity Genes Expression in Cardiac Tissue of Obese Rats Induced with High-Fat and Fructose Diet

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider