Why the study?
Recent studies have shown that brown adipose tissue can be localized using various conventional and molecular imaging modalities beyond FDG PET/CT.
What is the evidence for detecting brown adipose tissue in humans using various imaging techniques?
What is the evidence for detecting brown adipose tissue in humans using various imaging techniques?
This systematic review highlights that human brown adipose tissue, which is linked to reduced atherosclerotic disease risk, can be detected using multiple imaging modalities including PET/CT, CT, MRI, and SPECT.
BAT activation may reduce cardiometabolic risk; extends preclinical data and supports targeted human trials.
Brown adipose tissue (BAT) is involved in energy dissipation and has been linked to weight loss, insulin sensitivity, and reduced risk of atherosclerotic disease. BAT is found most often in the supraclavicular region, as well as mediastinal and paravertebral areas, and it is predominantly seen in young persons. BAT is activated by cold temperature and the sympathetic nervous system. In humans, BAT was initially detected via 2‐deoxy‐2‐[ 18 F]fluoro‐ d ‐glucose (FDG) positron emission tomography/computed tomography (PET/CT), a high‐resolution molecular imaging modality used to identify and stage malignancies. Recent studies have shown that BAT can be localized using conventional imaging modalities, such as CT or magnetic resonance imaging, as well as radiotracers used for single‐photon emission CT. In this systematic review, we have summarized the evidence for BAT detection in humans using various imaging techniques.
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Santhanam et al. (2021) studied this question.
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