April 15, 1999Journal of Clinical InvestigationOpen Access

Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men

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Why the study?

Does triglyceride enrichment of HDL enhance the metabolic clearance of HDL apo A-I in healthy men?

Population

12 healthy, normolipidemic men, mean age 29.7 +/- 2.7 years, mean BMI 24.4 +/- 1.2 kg/m2. Nonsmokers, no…

Comparison

Intravenous infusion of synthetic triglyceride… vs Autologous fasting HDL, radiolabeled and…

Design

Other

Follow-up

5 days

Authors

BLBenoı̂t LamarcheUniversité Laval KUKristine D. UffelmanUniversity of Toronto ACAndré C. CarpentierPreventive Cardiology

Discussion

Member takes

Implication

May explain low HDL-C in hypertriglyceridemia; hypothesis-generating and requires validation in larger studies.

Structured PICO

Does triglyceride enrichment of HDL enhance the metabolic clearance of HDL apo A-I in healthy men?

Population

12 healthy, normolipidemic men (n=6 in kinetic study, n=6 in composition study), mean age 29.7 +/- 2.7 years (kinetic group), mean BMI 24.4 +/- 1.2 kg/m2. Nonsmokers, no history of cardiovascular disease or systemic illness, not taking any pharmacologic agents.

Intervention

Intravenous infusion of synthetic triglyceride emulsion (Intralipid) for 5 hours (50 cc/h) to generate TG-enriched HDL, which was then radiolabeled and injected intravenously.

Comparator

Autologous fasting HDL (isolated prior to Intralipid infusion), radiolabeled and injected simultaneously.

Outcome

Fractional catabolic rate (FCR) of HDL-associated apo A-I over a 5-day periodsurrogate

Triglyceride enrichment of HDL directly enhances the metabolic clearance of HDL apo A-I in humans, providing a mechanistic explanation for low HDL cholesterol in hypertriglyceridemic states.

Cite This Study

Lamarche et al. (1999) studied this question.

synapsesocial.com/papers/6a766550656dd99464ec021b https://doi.org/10.1172/jci5286

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April 15, 1999Journal of Clinical InvestigationOpen Access

Triglyceride enrichment of HDL enhances in vivo metabolic clearance of HDL apo A-I in healthy men

View Full Paper

Ask AI

Bookmark

Why the study?

Does triglyceride enrichment of HDL enhance the metabolic clearance of HDL apo A-I in healthy men?

Population

12 healthy, normolipidemic men, mean age 29.7 +/- 2.7 years, mean BMI 24.4 +/- 1.2 kg/m2. Nonsmokers, no…

Comparison

Intravenous infusion of synthetic triglyceride… vs Autologous fasting HDL, radiolabeled and…

Design

Other

Follow-up

5 days

Authors

BLBenoı̂t LamarcheUniversité Laval KUKristine D. UffelmanUniversity of Toronto ACAndré C. CarpentierPreventive Cardiology

Discussion

Member takes

Implication

May explain low HDL-C in hypertriglyceridemia; hypothesis-generating and requires validation in larger studies.

Structured PICO

Does triglyceride enrichment of HDL enhance the metabolic clearance of HDL apo A-I in healthy men?

Population

Intervention

Intravenous infusion of synthetic triglyceride emulsion (Intralipid) for 5 hours (50 cc/h) to generate TG-enriched HDL, which was then radiolabeled and injected intravenously.

Comparator

Autologous fasting HDL (isolated prior to Intralipid infusion), radiolabeled and injected simultaneously.

Outcome

Fractional catabolic rate (FCR) of HDL-associated apo A-I over a 5-day periodsurrogate

Triglyceride enrichment of HDL directly enhances the metabolic clearance of HDL apo A-I in humans, providing a mechanistic explanation for low HDL cholesterol in hypertriglyceridemic states.

Cite This Study

Lamarche et al. (1999) studied this question.

synapsesocial.com/papers/6a766550656dd99464ec021b https://doi.org/10.1172/jci5286

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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