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August 25, 2016Thrombosis and Haemostasis

Usefulness of Health Registers for detection of bleeding events in outcome studies

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Why the study?

Do Swedish administrative health databases accurately detect major bleeding events in individuals with atrial fibrillation?

Population

78,022 individuals with atrial fibrillation in Stockholm County from 2006 to 2013

Comparison

Swedish administrative health databases using… vs Manual review of medical records

Design

Cohort, Medical records were studied and classified in a blinded and…

Follow-up

2006 to 2013

Authors

MSMika SkeppholmLFLeif Friberg

Discussion

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Overview

Swedish registers detect most major bleeds in AF; supports their use in safety studies but leaves validation needs open.

Structured PICO

Do Swedish administrative health databases accurately detect major bleeding events in individuals with atrial fibrillation?

P
Population
78,022 individuals with atrial fibrillation in Stockholm County from 2006 to 2013 (a random sample of n=761 patients' medical records were studied for validation)
I
Intervention
Swedish administrative health databases (Patient register and Cause of Death register) using diagnostic codes for bleeding
C
Comparator
Manual review of medical records
O
Outcome
Detection of major bleeding events (measured by sensitivity and specificity)

Swedish nationwide health registries demonstrate high sensitivity and specificity for detecting major bleeding events, validating their use in outcome studies.

Cite This Study

Skeppholm et al. (2016) studied this question.

synapsesocial.com/papers/6a76669ba1033ab89ebc53achttps://doi.org/10.1160/th16-05-0400
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ascertainment and validation of major bleeding events in a primary care database2018 · 12 citations
  2. 2Major bleeding with antithrombotic agents: a 2012–2015 study using the French nationwide Health Insurance database linked to emergency department records within five areas – rationale and design of <scp>SACHA</scp> study2018 · 10 citations
  3. 3A strategy for assessment and validation of major bleeding cases in a primary health care database in Spain2021 · 2 citations
  4. 4Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis2019 · 32 citations
  5. 5Atrial fibrillation in patients with ischaemic stroke in the Swedish national patient registers: how much do we miss?2014 · 25 citations