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December 10, 2018Fundamental and Clinical Pharmacology

Using six linkage keys, 5,264 hospital visits were matched with a clinically confirmed major haemorrhagic event from the emergency database out of 3,837,557 hospital visits in SNIIRAM.

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Why the study?

Previous studies showed inconsistent results on the safety profile of antithrombotic drugs, potentially due to varying bleeding definitions and classification bias from lack of medical evaluation.

What is the risk of major haemorrhagic events associated with different antithrombotic drugs in a real-world French cohort?

Population

3 837 557 hospital visits identified in SNIIRAM linked with emergency database records

Comparison

VKA vs NOAC, antiplatelet agents, and parenteral anticoagulants

Design

Database linkage study protocol and validation

Authors

JBJ. BougetFBFrédéric BalussonLSLucie‐Marie Scailteux

Discussion

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Overview

Linking nationwide health insurance data with clinical emergency records enables more accurate categorization and medical validation of major haemorrhagic events associated with antithrombotic drugs.

Structured PICO

What is the risk of major haemorrhagic events associated with different antithrombotic drugs in a real-world French cohort?

P
Population
Patients with hospital visits in the French nationwide Health Insurance database (SNIIRAM) linked to emergency department records within five areas (n=5,264 matched major haemorrhagic events).
I
Intervention
Antithrombotic drugs (vitamin K antagonist [VKA], non-VKA anticoagulant [NOAC], antiplatelet agent, parenteral anticoagulant)
C
Comparator
VKA vs NOAC (for specific comparison)
O
Outcome
Major haemorrhagic event and event-free survivalsafety

Linking nationwide health insurance data with clinical emergency records enables more accurate categorization and medical validation of major haemorrhagic events associated with antithrombotic drugs.

Limitations

  • 1,090 unmatched haemorrhagic events due to patients not extracted in the SNIIRAM database (e.g., military people, patients in specific accommodation establishments)

Cite This Study

Bouget et al. (2018) studied this question.

synapsesocial.com/papers/6a766343656dd99464ec0154https://doi.org/10.1111/fcp.12444
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