Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2024Cardiovascular ResearchOpen Access

IKKβ stabilizes Mitofusin 2 and suppresses doxorubicin cardiomyopathy

View Full Paper
Ask AI
Bookmark
Share

Why the study?

IKKβ suppresses mitochondrial injury in doxorubicin cardiomyopathy, but the underlying mechanism remained undefined.

Does IKKβ-mediated phosphorylation of MFN2 prevent doxorubicin-induced mitochondrial injury and cell death in cardiac myocytes?

Population

Cardiac myocytes treated with doxorubicin

Comparison

IKKβ or MFN2S53D gain of function vs controls or mutant variants

Design

Preclinical in vitro mechanistic study

Authors

MGMatthew GubermanSt. Boniface HospitalRDRimpy DhingraSt. Boniface HospitalJCJenna CrossUniversity of Manitoba

Discussion

Loading...

Member takes

Overview

May inform cardioprotective strategies in doxorubicin cardiomyopathy; hypothesis-generating for IKKβ-MFN2 axis modulation.

Structured PICO

Does IKKβ-mediated phosphorylation of MFN2 prevent doxorubicin-induced mitochondrial injury and cell death in cardiac myocytes?

P
Population
Cardiac myocytes treated with doxorubicin (in vitro model of doxorubicin cardiomyopathy)
I
Intervention
IKKβ gain of function or phosphomimetic MFN2 (MFN2S53D)
C
Comparator
Vehicle-treated cells, wild-type MFN2, or kinase-inactive mutant IKKβK-M
O
Outcome
MFN2 protein stability, mitochondrial injury (ROS production, respiration), and cell deathsurrogate

IKKβ protects against doxorubicin-induced cardiomyopathy by phosphorylating and stabilizing MFN2, revealing a novel survival pathway.

Cite This Study

Guberman et al. (2024) studied this question.

synapsesocial.com/papers/6a766b0eee08d608e595c40chttps://doi.org/10.1093/cvr/cvad145
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling2014 · 223 citations
  2. 2Bidirectional Regulation of Nuclear Factor-κB and Mammalian Target of Rapamycin Signaling Functionally Links Bnip3 Gene Repression and Cell Survival of Ventricular Myocytes2013 · 51 citations
  3. 3Mitofusin 2: from functions to disease2018 · 369 citations
  4. 4The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes2022 · 53 citations
  5. 5Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy2022 · 86 citations