Why the study?
Does global ischaemia and reperfusion under cardiopulmonary bypass alter beta-adrenergic signal transduction and contractility in the canine heart?
Does global ischaemia and reperfusion under cardiopulmonary bypass alter beta-adrenergic signal transduction and contractility in the canine heart?
Decreased contractility after cardiopulmonary bypass is likely due to cellular alterations distal to cAMP generation rather than depression of the beta-adrenergic system, which actually recovers to supranormal values.
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Post-CPB contractile failure may reflect post-cAMP defects; this canine model leaves open beta-adrenergic upregulation relevance in clinical ischaemia-reperfusion.
Dupuis et al. (1997) studied this question.
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