Why the study?
Major depressive disorder is linked to higher cardio-metabolic comorbidity, but heterogeneity is large and immune-inflammatory and metabolic dysregulation affects only a subset of cases.
Are specific depression dimensional profilers associated with immuno-metabolic dysregulation over time?
Population
>7000 observations across three waves in the Netherlands Study of Depression and Anxiety
Comparison
Four depression dimensional profilers
Design
Cross-sectional and longitudinal cohort study
Follow-up
6-year
Authors
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Atypical energy-related symptoms associate with worse immuno-metabolic profiles in MDD; leaves open prospective prediction of cardio-metabolic risk.
Are specific depression dimensional profilers associated with immuno-metabolic dysregulation over time?
Patients with atypical energy-related depression symptoms may represent a high-risk group for cardiometabolic disease who could benefit from targeted prevention.
Lamers et al. (2020) studied this question.
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