Why the study?
The study was conducted to investigate the protective effects and regulatory mechanism of miR-488-3p on doxorubicin-induced cardiotoxicity.
Does miR-488-3p overexpression prevent doxorubicin-induced cardiotoxicity in mouse models?
Population
C57BL/6 mice and primary cardiomyocytes
Comparison
miR-488-3p overexpression vs doxorubicin treatment alone
Design
Preclinical in vivo and in vitro study
Authors
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Should not change practice; hypothesis-generating for miR-488-3p in doxorubicin cardiotoxicity.
Does miR-488-3p overexpression prevent doxorubicin-induced cardiotoxicity in mouse models?
miR-488-3p protects against doxorubicin-induced cardiotoxicity by inhibiting CyclinG1, suggesting a potential therapeutic target for doxorubicin-induced cardiovascular diseases.
Yan et al. (2022) studied this question.
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