What question did this study set out to answer?

The study aims to investigate the role of survivin in cardiac function and cardiomyocyte number regulation.

March 11, 2008CirculationOpen Access

Survivin Determines Cardiac Function by Controlling Total Cardiomyocyte Number

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Population

alpha-myosin heavy chain-survivin mice, neonatal rat cardiomyocytes, and human cardiomyopathy samples

Comparison

Cardiac-specific deletion of survivin, survivin… vs Control/wild-type models

Design

Preclinical

Authors

BLBodo LevkauGeneral Cardiology MSMichael SchäfersUniversity of Münster JWJeremias WohlschlaegerDIAKO

Discussion

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Implication

Survivin is required for cardiomyocyte proliferation in mice; hypothesis-generating for regenerative targets in human heart failure.

Key Points

The study aims to investigate the role of survivin in cardiac function and cardiomyocyte number regulation.
Cardiac-specific deletion of survivin assessed in alpha-myosin heavy chain (MHC)-survivin(-/-) mice.
Cardiomyocyte numbers quantified using a stereological method.
Interventions included adenoviral overexpression and small interfering RNA knockdown of survivin in neonatal rat cardiomyocytes.
Cardiac-specific survivin deletion led to approximately 50% lower mitotic rate and premature cardiac death.
Survivin-deficient cardiomyocytes showed marked DNA polyploidy without increased apoptosis.
Survivin expression positively correlated with cardiomyocyte DNA content in human cardiomyopathy.

Structured PICO

Population

alpha-myosin heavy chain (MHC)-survivin(-/-) mice, neonatal rat cardiomyocytes, and human cardiomyopathy samples

Intervention

Cardiac-specific deletion of survivin, survivin siRNA knockdown, and adenoviral overexpression of survivin

Comparator

Control/wild-type models

Outcome

Cardiac function and total cardiomyocyte numbersurrogate

Survivin plays a critical role in determining total cardiomyocyte number through regulation of replication, and its deficiency leads to progressive heart failure.

Cite This Study

Levkau et al. (2008) studied this question.

synapsesocial.com/papers/6a7674b8232067cbf2ec09ac https://doi.org/10.1161/circulationaha.107.734160

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Survivin Determines Cardiac Function by Controlling Total Cardiomyocyte Number

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Survivin Determines Cardiac Function by Controlling Total Cardiomyocyte Number

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider