Population
In vitro kinase models and mouse fibroblast cells
Comparison
Diamide and reduced glutathione vs Mutant kinase or untreated cells
Design
Preclinical
Authors
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Hypothesis-generating for PKA redox regulation; leaves open relevance to human cardiovascular disease without further validation.
This study identifies glutathionylation at cysteine 199 as a novel oxidative mechanism for the reversible regulation of cAMP-dependent protein kinase activity.
Humphries et al. (2002) studied this question.
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