What question did this study set out to answer?

The aim is to summarize current understanding of cyclin D1 regulation and its oncogenic role in human cancers.

Nuclear cyclin D1: An oncogenic driver in human cancer

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Review highlights cyclin D1's role in oncogenic transformation through nuclear retention mechanisms.

The aim is to summarize current understanding of cyclin D1 regulation and its oncogenic role in human cancers.
Overview of mechanisms affecting cyclin D1 regulation in various human cancers.
Discussion on nuclear trafficking and proteolysis of cyclin D1.
Analysis of how these factors contribute to neoplastic transformation.
Cyclin D1 overexpression is common in cancers but not solely responsible for oncogenic transformation.
Nuclear retention of cyclin D1 is essential for its oncogenic effects.
Several mechanisms contribute to aberrant cyclin D1 regulation that leads to cancer progression.

Kim et al. (2009) studied this question.

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