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January 1, 2017Journal of Experimental BiologyOpen Access

Differences in titin segmental elongation between passive and active stretch in skeletal muscle

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Population

Rabbit psoas myofibrils labeled with fluorescent F146 antibody

Comparison

Active stretch (high calcium) vs Passive stretch (no calcium)

Design

Preclinical

Authors

MDMichael DuVallNivalis Therapeutics (United States)AJAzim JinhaUniversity of CalgaryGSGudrun Schappacher‐TilpFH JOANNEUM University of Applied Sciences

Discussion

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Implication

Questions exclusive actin-myosin force generation during active stretch; leaves open titin integration into contraction theories.

Structured PICO

P
Population
Rabbit psoas myofibrils labeled with fluorescent F146 antibody
I
Intervention
Active stretch (high calcium)
C
Comparator
Passive stretch (no calcium)
O
Outcome
Length changes of proximal and distal titin segmentssurrogate

Calcium activation increases titin segment stiffness during active stretch, contributing to active muscle force regulation independent of actin binding.

Cite This Study

DuVall et al. (2017) studied this question.

synapsesocial.com/papers/6a767978ed4768d249c4482bhttps://doi.org/10.1242/jeb.160762
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Connectin, an Elastic Protein of Muscle. Identification of “Titin” with Connectin11981 · 153 citations
  2. 2Force enhancement following stretch in a single sarcomere2010 · 134 citations
  3. 3The origin of passive force enhancement in skeletal muscle2007 · 137 citations
  4. 4Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium2012 · 77 citations
  5. 5Work Done by Titin Protein Folding Assists Muscle Contraction2016 · 190 citations