Population
Mechanically isolated single sarcomeres
Comparison
Active stretching vs Held at a constant length (isometric contraction)
Design
Preclinical
Authors
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Challenges nonuniformity theory in isolated sarcomeres; leaves open titin-based mechanisms in intact cardiac muscle.
Residual force enhancement following active stretching is preserved in single sarcomeres, challenging the sarcomere length nonuniformity theory and suggesting intrinsic mechanisms such as titin regulation.
Leonard et al. (2010) studied this question.
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