Why the study?
Do glucocorticoids and immunosuppressants improve necrosis, regeneration, or serum creatine kinase activity in mdx mice?
Do glucocorticoids and immunosuppressants improve necrosis, regeneration, or serum creatine kinase activity in mdx mice?
Glucocorticoids and immunosuppressants do not improve muscle necrosis, regeneration, or creatine kinase levels in mdx mice, contrasting with their beneficial effects in human Duchenne muscular dystrophy.
Therapeutic doses of methylprednisolone, azathioprine, cyclosporin A, and cyclophosphamide administered to mdx mice between 15 and 45 days of age failed to significantly influence the time course and prevalence of necrosis and regeneration or serum creatine kinase activity. This finding contrasts with previously reported findings of beneficial effects of glucocorticoids in Duchenne muscular dystrophy (DMD). This may indicate that, mechanisms upon which beneficial effects of glucocorticoids depend in DMD, do not operate (sufficiently) in mdx mice.
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Weller et al. (1991) studied this question.
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