What question did this study set out to answer?

This study investigates how arterial viscoelasticity and dimensions affect wave propagation in dog femoral arteries.

December 1, 1978Circulation Research

The relation between arterial viscoelasticity and wave propagation in the canine femoral artery in vivo.

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Population

9 anesthetized dogs (16 experiments on the femoral artery)

Comparison

In vivo measurement of arterial viscoelasticity… vs Predictions from theoretical linear models of…

Design

Preclinical

Authors

WMWilliam R. MilnorJohns Hopkins University CBChristopher BertramThe University of Sydney

Discussion

Member takes

Implication

Linear models underestimate canine arterial attenuation >2-fold; challenges their use for pulsatile flow and leaves open human validation.

Key Points

This study investigates how arterial viscoelasticity and dimensions affect wave propagation in dog femoral arteries.
Conducted 16 experiments on the femoral artery in nine anesthetized dogs.
Used a two-point pressure and flow technique to measure wave propagation.
Measured vessel diameter with an ultrasonic micrometer during varying pressure states.
Measured attenuation constants ranged from 0.010 at 1.3 Hz to 0.075 at 12.7 Hz, exceeding model predictions.
True phase velocity increased from 6.71 m/sec at 1.3 Hz to 10.54 m/sec at 12.7 Hz, aligning with the Cox model but lower than Jager's.
Resistive component of longitudinal impedance was significantly greater than model predictions across all frequencies.

Structured PICO

Population

9 anesthetized dogs (16 experiments on the femoral artery)

Intervention

In vivo measurement of arterial viscoelasticity, diameter, wall thickness, propagation coefficients, and impedances using a two-point pressure and flow technique and an ultrasonic micrometer

Comparator

Predictions from theoretical linear models of blood flow (Cox model and Jager model)

Outcome

Wave propagation coefficients (attenuation constants and true phase velocity) and longitudinal impedancesurrogate

In vivo measurements in canine femoral arteries demonstrate that standard linear models of blood flow produce significant errors when calculating pulsatile blood flow or attenuation from arterial viscoelasticity.

Limitations

The experiments do not identify the source of the discrepancies between measured values and model predictions.

Cite This Study

Milnor et al. (1978) studied this question.

synapsesocial.com/papers/6a767d0ef91c041860c44a90 https://doi.org/10.1161/01.res.43.6.870

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December 1, 1978Circulation Research

The relation between arterial viscoelasticity and wave propagation in the canine femoral artery in vivo.

View Full Paper

Ask AI

Bookmark

Population

9 anesthetized dogs (16 experiments on the femoral artery)

Comparison

In vivo measurement of arterial viscoelasticity… vs Predictions from theoretical linear models of…

Design

Preclinical

Authors

WMWilliam R. MilnorJohns Hopkins University CBChristopher BertramThe University of Sydney

Discussion

Member takes

Implication

Linear models underestimate canine arterial attenuation >2-fold; challenges their use for pulsatile flow and leaves open human validation.

Key Points

This study investigates how arterial viscoelasticity and dimensions affect wave propagation in dog femoral arteries.
Conducted 16 experiments on the femoral artery in nine anesthetized dogs.
Used a two-point pressure and flow technique to measure wave propagation.
Measured vessel diameter with an ultrasonic micrometer during varying pressure states.
Measured attenuation constants ranged from 0.010 at 1.3 Hz to 0.075 at 12.7 Hz, exceeding model predictions.
True phase velocity increased from 6.71 m/sec at 1.3 Hz to 10.54 m/sec at 12.7 Hz, aligning with the Cox model but lower than Jager's.
Resistive component of longitudinal impedance was significantly greater than model predictions across all frequencies.

Structured PICO

Population

9 anesthetized dogs (16 experiments on the femoral artery)

Intervention

In vivo measurement of arterial viscoelasticity, diameter, wall thickness, propagation coefficients, and impedances using a two-point pressure and flow technique and an ultrasonic micrometer

Comparator

Predictions from theoretical linear models of blood flow (Cox model and Jager model)

Outcome

Wave propagation coefficients (attenuation constants and true phase velocity) and longitudinal impedancesurrogate

Limitations

The experiments do not identify the source of the discrepancies between measured values and model predictions.

Cite This Study

Milnor et al. (1978) studied this question.

synapsesocial.com/papers/6a767d0ef91c041860c44a90 https://doi.org/10.1161/01.res.43.6.870

Also Consider

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