Corticosteroids in Septic Shock

This is the authors' abstract. We don't add key points for this paper.

As the balance of evidence regarding corticosteroid treatment for septic shock shifts once again toward the negative, the study by Sprung et al.1 in this issue of the Journal elicits a strong feeling of déjà vu. Will the historical fate of high-dose corticosteroids, which were largely abandoned when the benefit observed in early studies could not be replicated in larger trials,2,3 now befall “physiologic-dose” corticosteroids?The rationale for therapy with corticosteroids at a physiologic dose (i.e., 200 to 300 mg of hydrocortisone per day) originated in the observations that patients with septic shock who had a reduced response to . . .