Key result
High-dose corticosteroids did not improve overall hospital mortality compared to control in patients with severe septic shock (76.7% vs 69%).
Why the study?
Do high-dose corticosteroids improve survival or shock reversal in patients with severe septic shock?
RCT (n=59)
Randomized
Do high-dose corticosteroids improve survival or shock reversal in patients with severe septic shock?
Absolute Event Rate: 76.7% vs 69%
High-dose corticosteroids do not improve overall hospital survival in patients with severe, late septic shock, despite transient early benefits in shock reversal.
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High-dose corticosteroids should not be used to improve survival in severe septic shock; confirms no mortality benefit on primary RCT endpoint.
Sprung et al. (1984) conducted an RCT in Severe septic shock (n=59). High-dose corticosteroids (methylprednisolone or dexamethasone) vs. Control was evaluated on Overall hospital mortality. High-dose corticosteroids did not improve overall hospital mortality compared to control in patients with severe septic shock (76.7% vs 69%).
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