What question did this study set out to answer?

To evaluate the efficacy and safety of high-dose methylprednisolone sodium succinate in preventing shock, reversing shock, and reducing mortality in severe sepsis and septic shock.

September 10, 1987New England Journal of Medicine

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

View Full Paper

Ask AI

Bookmark

Authors

RBRoger C. BoneUniversity of Arkansas at Little Rock CFCharles J. FisherUniversity of Toledo Medical Center TCTerry P. ClemmerIntermountain Healthcare

Discussion

Member takes

Implication

Randomized double-blind trial shows high-dose methylprednisolone does not improve survival in severe sepsis or septic shock, indicating lack of benefit and potential harm.

Key Points

To evaluate the efficacy and safety of high-dose methylprednisolone sodium succinate in preventing shock, reversing shock, and reducing mortality in severe sepsis and septic shock.
Prospective, randomized, double-blind, placebo-controlled trial enrolling 382 patients with clinical suspicion of infection, systemic inflammatory signs, and evidence of organ dysfunction.
Patients received either methylprednisolone sodium succinate (30 mg/kg) or placebo in four infusions, initiated within two hours of diagnosis.
No significant differences occurred between groups in overall mortality, prevention of shock, or reversal of shock.
Among patients with baseline serum creatinine >2 mg/dL, 14-day mortality was significantly higher with methylprednisolone than placebo (46 of 78 [59%] vs. 17 of 58 [29%]; P < 0.01).
Patients receiving methylprednisolone experienced significantly more fatalities related to secondary infection.

Cite This Study

Bone et al. (1987) studied this question.

synapsesocial.com/papers/6a7d3226e9ddcd9870aa12a2 https://doi.org/10.1056/nejm198709103171101

View Full Paper

Ask AI

Bookmark

Implication

Randomized double-blind trial shows high-dose methylprednisolone does not improve survival in severe sepsis or septic shock, indicating lack of benefit and potential harm.

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

Discussion

Member takes

Implication

Key Points

Cite This Study

A Controlled Clinical Trial of High-Dose Methylprednisolone in the Treatment of Severe Sepsis and Septic Shock

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider