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April 4, 2026Open Access

Efficacy of Low-dose vs High-dose Pulse Therapy of Methylprednisolone on Selected Clinical Outcomes among Moderate to Severe COVID-19 Patients: A Retrospective Observational Study from Intensive Care Units

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Authors

JDJonny DhawanPMPriyanka MengiGSGurpreet Singh

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Overview

Retrospective observational study compares mortality and mechanical ventilation needs in COVID-19 patients receiving different methylprednisolone doses, suggesting low-dose may be better.

Key Points

  • To compare the efficacy of low-dose versus high-dose methylprednisolone on clinical outcomes in moderate to severe COVID-19 patients.
  • Retrospective observational study conducted at a tertiary care hospital.
  • Reviewed electronic medical records of 300 adult COVID-19 patients from February 2020 to February 2022.
  • Patients categorized into low-dose (40 mg/day) and high-dose (120 mg/day) groups based on steroid treatment.
  • Low-dose group had lower mortality rates (26.5%) compared to high-dose group (35.3%).
  • Higher percentage of patients in the high-dose group required mechanical ventilation (95.3%) compared to low-dose group (86%).
  • High-dose patients had a significantly higher incidence of severe ARDS (50.6% vs 27.9%).

Cite This Study

Dhawan et al. (2026) studied this question.

synapsesocial.com/papers/69d0ae68659487ece0fa45behttps://doi.org/10.5005/jactem-11048-0023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Methylprednisolone pulse therapy compared with intravenous dexamethasone for severe COVID-19 patients: a randomized clinical trial2025
  2. 2The impact of different corticosteroids in hospitalised patients with severe COVID-19 pneumonia: a retrospective observational study2024
  3. 3High-Dose or Low-Dose Corticosteroids – Which Regimen is More Effective in Patients with Moderate to Severe COVID-19? A Retrospective Study2024
  4. 4Which Dose of Pulse Steroid Therapy is More Effective in Oxygen-Requiring Patients Aged 25–65 Hospitalized with SARS-Cov-2 Diagnosis?2026
  5. 5Comparative Efficacy of Inhaled and Intravenous Corticosteroids in Managing COVID-19-Related Acute Respiratory Distress Syndrome2024 · 2 citations