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May 16, 2026DAHUDER Medical JournalOpen Access

Which Dose of Pulse Steroid Therapy is More Effective in Oxygen-Requiring Patients Aged 25–65 Hospitalized with SARS-Cov-2 Diagnosis?

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Authors

STSerhat Mert TirilSBSema Basat

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Overview

Randomized trial evaluates clinical outcomes of different steroid doses in COVID-19 patients, indicating timing is crucial for survival.

Key Points

  • This study aims to determine the effectiveness of different doses of pulse steroid therapy in hospitalized patients with COVID-19 requiring oxygen support.
  • Randomized trial of 61 hospitalized patients aged 25–65 with respiratory distress.
  • Patients received either 250 mg (n=31) or 500 mg (n=30) of methylprednisolone.
  • Data on comorbidities, CT features, laboratory parameters, and clinical outcomes were analyzed.
  • No statistically significant difference in clinical outcomes between treatment groups (p > 0.05).
  • Mortality was significantly associated with comorbidities (OR=7.58, p=0.033) and elevated baseline CRP levels (OR=6.76, p=0.009).
  • Timing of steroid therapy initiation influenced survival more than the steroid dose (OR=5.72, p=0.012).

Cite This Study

Tiril et al. (2026) studied this question.

synapsesocial.com/papers/6a080ae2a487c87a6a40cf32https://doi.org/10.56016/dahudermj.1922242
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy of Low-dose vs High-dose Pulse Therapy of Methylprednisolone on Selected Clinical Outcomes among Moderate to Severe COVID-19 Patients: A Retrospective Observational Study from Intensive Care Units2026
  2. 2Methylprednisolone pulse therapy compared with intravenous dexamethasone for severe COVID-19 patients: a randomized clinical trial2025
  3. 3The impact of different corticosteroids in hospitalised patients with severe COVID-19 pneumonia: a retrospective observational study2024
  4. 4Efficacy of different doses of corticosteroids in treating severe COVID-19 pneumonia2024 · 9 citations
  5. 5High-Dose or Low-Dose Corticosteroids – Which Regimen is More Effective in Patients with Moderate to Severe COVID-19? A Retrospective Study2024