A study of methylprednisolone in cardiac surgery

Background: Cardiac surgery is associated with Post systematic inflammatory response. Use of steroids in cardiac surgery is controversial. Aim and objective: To study the effect of methylprednisolone in patients with cardiac surgery at a tertiary health care centre Methodology: Present study was a randomized control trial carried out on patients undergoing Coronary Artery Bypass Graft surgery. Total 60 patients were studied. Group 1 received intravenous methylprednisolone sodium succinate and Group 2 received intravenous isotonic sodium chloride solution. Study outcome was measured as major adverse event like death, myocardial infarction (MI), stroke, renal failure, or respiratory failure, occurring within 30 days, postoperative infections; postoperative atrial fibrillation; highest serum glucose concentration in the ICU and time to discharge from the ICU and from the hospital. Results: Extubation time in methyl prednisolone group (12.2 1.3 hours) significantly hogher than normal saline group (10.1 1.5 hours). Highest serum glucose concentration was significantly higher in MP group than NS group (p<0.05). Post operative infection was significantly higher in normal saline group (26.67%) than methyl prednisolone group (13.33%) (p<0.05).