Why the study?
Cardiac rehabilitation has been associated with improved cardiac function in cardiovascular diseases, prompting exploration of the factors associated with cardiac function and cardiac rehabilitation.
Does cardiac rehabilitation reduce MACEs and improve cardiac function in STEMI patients undergoing primary PCI?
Does cardiac rehabilitation reduce MACEs and improve cardiac function in STEMI patients undergoing primary PCI?
Cardiac rehabilitation for 6 months significantly improves functional capacity, left ventricular ejection fraction, and reduces major adverse cardiac events in STEMI patients post-primary PCI.
BACKGROUND: Cardiac rehabilitation (CR) has been associated with improved cardiac function in cardiovascular diseases. Our aim was to explore the factors associated with cardiac function and CR. METHODS: ), number of diseased vessels, arrhythmia during PCI, N-terminal pro-B-type natriuretic peptide (NT-proBNP), left ventricular ejection fraction (LVEF) and major adverse cardiac events (MACEs) at 6 months after PCI were compared. Then, the clinical characteristics of patients were further analyzed according to those with MACEs (n = 78) and those without MACEs (n = 395). RESULTS: After CR of 6 months, NT-proBNP levels (p = 0.027), 6-MWD (meter, P = 0.000), LVEF (P = 0.000) were significantly improved in group A compared to group B, but not for SMWA (P = 0.875). Multivariate analysis indicated that even though patients in group A (OR 3.06, 95% CI 1.132-8.274, p = 0.03) have a higher incidence of hyperlipidemia, their MACEs (OR 0.191, 95% CI 0.038-0.961, p = 0.05) at 6 months were significantly lower than in group B, mainly because the average patient low age (<65 years, OR 0.917, 95% CI 0.859-0.979, p = 0.01) and significant improvement of 6-MWD (OR 7.999, 95% CI 4.342-14.737, P = 0.00) and the LVEF at 6 months (OR 1.112, 95% CI 1.072-1.154, p = 0.00). Further analysis based on the MACES outcomes showed that there were 6 factors associated with the occurrence of MACEs, they were age >65 years (OR 1.032, 95% CI 1.009-1.009, p = 0.007), smoking history (OR 0.485, 95% CI 0.238-0.989, p = 0.046), education level (OR 2.646, 95% CI 1.370-5.108, p = 0.004), 6-MWD (OR 1.688, 95% CI 1.104-2.811, p = 0.044), LVEF (OR 0.958, 95% CI 0.926-0.991, p = 0.013) and CR (OR 6.271, 95% CI 2.236-17.590, p = 0.000). CONCLUSION: CR, including exercise rehabilitation, is a beneficial option to reduce MACEs in STEMI patients treated with primary PCI.
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Ma et al. (2021) studied this question.
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