Why the study?
Does atropine treatment resolve hypotension and conduction disorders in patients poisoned by mad honey?
Does atropine treatment resolve hypotension and conduction disorders in patients poisoned by mad honey?
Ingestion of 'mad' honey containing andromedotoxin can cause significant bradycardia, AV block, and hypotension, which resolve completely with atropine therapy.
Atropine may resolve mad honey toxicity symptoms; hypothesis-generating and should not change practice without controlled data.
An unusual type of food poisoning is commonly seen in the Black Sea coast of Turkey attributable to andromedotoxin containing toxic honey ingestion. This study is a retrospective case series of 19 patients admitted to an emergency department in 2002, poisoned by "mad" honey. All of the patients had the complaints of nausea, vomiting, sweating, dizziness, and weakness, several hours after ingesting "mad" honey. Physical examination showed hypotension in 15 patients, sinus bradycardia in 15, and complete atrioventricular block (AVB) in four patients on admission. Two patients with bradycardia and two with AVB fell and injured their heads. Three of them presented with local haematoma. One patient had a 6 cm cut on his head without any neurological deficit and his cranial computed tomography imaging was normal. Hypotension and conduction disorders resolved with atropine treatment, resulting in complete recovery within 24 hours.
No takes yet. Share an insight, caveat, or question.
Hakan Özhan (2004) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: