Why the study?
Are specific genetic variants associated with severe statin-induced myopathy?
Population
Patients with severe statin myopathy and statin-tolerant controls
Design
Case-control
Authors
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EYS variants may increase severe statin myopathy susceptibility; hypothesis-generating and requires validation before clinical use.
Are specific genetic variants associated with severe statin-induced myopathy?
Variants in the EYS gene may confer genetic susceptibility to severe statin-induced myopathy, suggesting a role for EYS in skeletal muscle integrity.
Isackson et al. (2011) studied this question.
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