Tamoxifen-induced Cre recombinase activation in the Myh6-MerCreMer mouse model causes transient systolic dysfunction and cardiac hypertrophy, which must be accounted for in experimental designs.
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Transient tamoxifen effects mandate tamoxifen-only controls in Myh6-MerCreMer studies; extends methodological caution to genetic cardiac research.
Hall et al. (2011) studied this question.
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