Age-related changes in tissue macrophages precede cardiac functional impairment
Population
Cx3cr1(GFP/+) mouse reporter line
Comparison
Aging (≥30 weeks of age) vs Young mice (<10 weeks old)
Design
Preclinical
Follow-up
up to 30 weeks of age
Authors
Discussion
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Member takes
Implication
May implicate fibrogenic macrophage subsets in murine cardiac fibrosis; hypothesis-generating and requires human validation.
Structured PICO
P
Population
Cx3cr1(GFP/+) mouse reporter line
I
Intervention
Aging (≥30 weeks of age)
C
Comparator
Young mice (<10 weeks old)
O
Outcome
Phenotypic and gene expression changes in cardiac tissue macrophage subsetssurrogate
Aging induces early phenotypic shifts in murine cardiac tissue macrophages towards a fibrogenic gene expression profile, potentially contributing to age-associated cardiac fibrosis.
Cite This Study
Pinto et al. (2014) studied this question.