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A DNA endonuclease has been partially purified from Escherichia coli after infection with bacteriophage λ. The endonuclease, which is not present in uninfected cells or uninduced λ lysogens, catalyzes a magnesium-dependent reaction in which double strand breaks are introduced into duplex DNA. It is active on E. coli and T4 DNA, as well as on λ DNA. At least 1000 breaks can be introduced into λ DNA. A site which is essential for the synthesis of the endonuclease has been identified within the b2 region of the λ genome, but the physiological function of the endonuclease has not been established.
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Rhoades et al. (1973) studied this question.
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