What question did this study set out to answer?

To evaluate the impact of the COVID-19 pandemic on the operating characteristics and outcomes of the CAPTURE screening tool for identifying undiagnosed clinically significant COPD in primary care.

October 16, 2023Annals of the American Thoracic SocietyOpen Access

Impact of the COVID-19 Pandemic on Outcomes of CAPTURE: A Primary Care Chronic Obstructive Pulmonary Disease Screening Clinical Trial

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Authors

BYBarbara P. YawnUniversity of Minnesota BMBarry J. MakeJohns Hopkins University DMDavid M. ManninoRutgers, The State University of New Jersey

Discussion

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Implication

Clinical trial reveals pandemic-related visit restrictions altered screening outcomes for undiagnosed chronic obstructive pulmonary disease in primary care, indicating potential selection bias.

Key Points

To evaluate the impact of the COVID-19 pandemic on the operating characteristics and outcomes of the CAPTURE screening tool for identifying undiagnosed clinically significant COPD in primary care.
Enrolled adults aged 45–80 years without prior COPD diagnoses across 100 primary care practices within seven research networks across prepandemic (October 2018–March 2020) and post-resumption (August 2020–April 2022) periods.
Evaluated participant demographics, health history, COPD Assessment Test scores, modified Medical Research Council dyspnea index, and CAPTURE tool metrics (five-question survey and peak expiratory flow rate).
Defined clinically significant COPD via post-bronchodilator spirometry (FEV1/FVC < 0.70, or < 0.65 without post-bronchodilator data, plus FEV1 < 60% predicted or ≥1 exacerbation in the prior 12 months) under pandemic protocols that excluded patients with acute respiratory symptoms.
Pandemic safety protocols requiring verbal COVID-19 screening and the exclusion of patients with acute respiratory symptoms altered the clinical trial enrollment pool upon study resumption.
Differences in participant demographics, respiratory symptoms, and CAPTURE tool operating characteristics emerged between the prepandemic and post-resumption cohorts due to clinical visit restrictions.

Cite This Study

Yawn et al. (2023) studied this question.

synapsesocial.com/papers/6a76882c756dc91b14c3aa3f https://doi.org/10.1513/annalsats.202305-478rl

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Implication

Clinical trial reveals pandemic-related visit restrictions altered screening outcomes for undiagnosed chronic obstructive pulmonary disease in primary care, indicating potential selection bias.

Impact of the COVID-19 Pandemic on Outcomes of CAPTURE: A Primary Care Chronic Obstructive Pulmonary Disease Screening Clinical Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of the COVID-19 Pandemic on Outcomes of CAPTURE: A Primary Care Chronic Obstructive Pulmonary Disease Screening Clinical Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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