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June 15, 2021Clinical Hemorheology and Microcirculation

Peripheral microvascular dysfunction is also present in patients with ischemia and no obstructive coronary artery disease (INOCA)

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Why the study?

In patients with INOCA, coronary microvascular dysfunction carries a higher rate of MACE, but whether microvascular dysfunction can be detected noninvasively in the peripheral circulation remained to be demonstrated.

Is peripheral microvascular dysfunction detectable noninvasively in patients with INOCA compared to healthy controls?

Population

25 patients with INOCA and 25 apparently healthy controls

Comparison

Patients with INOCA vs apparently healthy controls

Authors

CJCamillo L. C. JunqueiraEFEsmeralci FerreiraUniversidade do Estado do Rio de JaneiroAJAdriana Silva Monteiro JunqueiraDASA (Brazil)

Discussion

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Implication

Nailfold videocapillaroscopy may detect peripheral microvascular changes in INOCA; leaves open its role as a noninvasive surrogate for coronary microvascular dysfunction.

Structured PICO

Is peripheral microvascular dysfunction detectable noninvasively in patients with INOCA compared to healthy controls?

P
Population
25 patients with ischemia and no obstructive coronary artery disease (INOCA) and 25 apparently healthy individuals (controls)
I
Intervention
Nailfold videocapillaroscopy (NVC) and venous occlusion plethysmography (VOP) to evaluate peripheral microvascular function, along with blood collection for biomarkers (sVCAM-1, ET-1, CRP)
C
Comparator
Apparently healthy individuals (controls)
O
Outcome
Peripheral microvascular function parameters including red blood cell velocity (RBCV), RBCVmax, time to reach maximal RBCV (TRBCVmax), and maximal blood flowsurrogate

Patients with INOCA exhibit detectable peripheral microvascular dysfunction, suggesting that the microvascular impairment extends systemically beyond the coronary circulation.

Cite This Study

Junqueira et al. (2021) studied this question.

synapsesocial.com/papers/6a7689333da069e66cbd3c5ehttps://doi.org/10.3233/ch-201065

Topics

Coronary artery diseaseCoronary CT angiography
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between cardiovascular risk factors and coronary microvascular dysfunction in cardiac syndrome X2010 · 56 citations
  2. 2Predictive Value of Reactive Hyperemia for Cardiovascular Events in Patients With Peripheral Arterial Disease Undergoing Vascular Surgery2007 · 263 citations
  3. 3Reactive hyperemia: a review of methods, mechanisms, and considerations2020 · 243 citations