This editorial highlights the ADAPTABLE trial as a major step forward in establishing pragmatic, patient-centric trial designs using electronic health records in the United States.
The publication in the Journal of the results of ADAPTABLE (Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness)1 comparing two doses of aspirin for the secondary prevention of cardiovascular disease represents a major step forward in establishing the pragmatic trial as an investigatory tool in the United States. The authors used a range of innovative and low-cost methods to simplify the identification, recruitment, and follow-up of patients: for example, algorithms were used to interrogate electronic health record data to identify eligible patients within the National Patient-Centered Clinical Research Network (PCORnet); patients could access a Web portal to give . . .
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Colin Baigent (2021) studied this question.
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