Key result
Lower body weight is linked to ~5% higher periprocedural bleeding risk during elective PCI.
Why the study?
Optimal anticoagulation during elective PCI remains uncertain, particularly in East Asian populations with lower body weight and increased bleeding susceptibility.
Does body weight or unfractionated heparin dose predict periprocedural bleeding in Japanese patients undergoing elective PCI?
Cohort (n=348)
No
Does body weight or unfractionated heparin dose predict periprocedural bleeding in Japanese patients undergoing elective PCI?
Odds Ratio: 0.948 (95% CI 0.905–0.994)
p-value: p=0.027
Supports consideration of body weight in elective PCI bleeding risk; hypothesis-generating for weight-adjusted UFH dosing in East Asian cohorts.
Background Optimal anticoagulation during elective percutaneous coronary intervention (PCI) remains uncertain, particularly in East Asian populations with lower body weight and increased bleeding susceptibility. We investigated the association of body weight and unfractionated heparin (UFH) dose with periprocedural bleeding during elective PCI. Methods and Results This retrospective single-center study included 348 Japanese patients undergoing elective PCI. Patients received either fixed-dose UFH (10,000 U) or weight-adjusted UFH (100 U/kg). Within the fixed-dose group, patients were stratified according to weight-adjusted UFH exposure (≥150 vs. <150 U/kg). The primary endpoint was Bleeding Academic Research Consortium (BARC) type 1 or 2 bleeding. Bleeding events were less frequent in the low-dose than in the high-dose group (24% vs. 40%, P < 0.001). No significant differences in major cardiovascular events were observed during follow-up. In multivariable analysis, lower body weight was associated with increased bleeding risk (OR 0.948, 95% CI 0.905–0.994, P = 0.027), whereas UFH dose was not independently associated with bleeding. Conclusions Lower body weight may be more closely associated with periprocedural bleeding than UFH dose during elective PCI. Careful bleeding risk assessment may therefore be warranted in patients with low body weight undergoing PCI.
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Honda et al. (2026) conducted a cohort in Stable or unstable angina pectoris requiring elective PCI (n=348). Lower body weight vs. Higher body weight was evaluated on Bleeding Academic Research Consortium (BARC) type 1 or 2 bleeding (OR 0.948, 95% CI 0.905-0.994, p=0.027). Lower body weight was independently associated with increased periprocedural bleeding risk (OR 0.948) during elective PCI, whereas unfractionated heparin dose was not.