Why the study?
Parturients with vascular Ehlers-Danlos syndrome face a particular risk of hemorrhage, but little evidence exists to guide its prevention or management.
Does administration of desmopressin and tranexamic acid improve hemostasis in a patient with vascular Ehlers-Danlos syndrome during cesarean delivery?
Does administration of desmopressin and tranexamic acid improve hemostasis in a patient with vascular Ehlers-Danlos syndrome during cesarean delivery?
Desmopressin and tranexamic acid may be beneficial for achieving hemostasis during major obstetric hemorrhage in patients with vascular Ehlers-Danlos syndrome.
May warrant consideration in vascular Ehlers-Danlos syndrome hemorrhage; leaves open efficacy pending prospective data.
Parturients with vascular Ehlers-Danlos syndrome are at particular risk of hemorrhage, and there is little evidence to guide prevention or management of hemorrhage in these patients. We present the case of a patient with vascular Ehlers-Danlos syndrome who had a cesarean delivery complicated by an intraoperative hemorrhage. Administration of desmopressin and tranexamic acid appeared to be of marked benefit in achieving hemostasis. To the best of our knowledge, this is the first report of the use of desmopressin during major obstetric hemorrhage in vascular Ehlers-Danlos syndrome.
No takes yet. Share an insight, caveat, or question.
Grant et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: