Why the study?
Does a high-fat Western diet alter liver gene expression and accelerate atherosclerosis in LDLR-/- mice?
Does a high-fat Western diet alter liver gene expression and accelerate atherosclerosis in LDLR-/- mice?
A high-fat Western diet induces components of the alternative complement pathway in the liver, suggesting a potential mechanism for accelerated atherosclerosis.
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Western diet-induced hepatic complement changes merit mechanistic follow-up in atherosclerosis models; leaves open human relevance and clinical implications.
Recinos et al. (2004) studied this question.
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