Association Between Adiposity and Lean Mass With Long‐Term Cardiovascular Events in Patients With Coronary Artery Disease: No Paradox
Why the study?
Does high body fat percentage increase the risk of major adverse cardiovascular events in patients with coronary artery disease?
Population
717 patients referred to cardiac rehabilitation after coronary artery disease events or procedures, mean age…
Comparison
Highest quartile of body fat percentage and… vs Lowest quartile of body fat percentage and…
Design
Cohort
Follow-up
median 3.9 years
Authors
Discussion
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Member takes
Implication
May refine MACE risk stratification via body composition in CAD rehab; leaves open whether targeting fat mass improves outcomes.
Structured PICO
Does high body fat percentage increase the risk of major adverse cardiovascular events in patients with coronary artery disease?
P
Population
717 patients referred to cardiac rehabilitation after coronary artery disease events or procedures, mean age 61.4 years, 75% men.
I
Intervention
Highest quartile of body fat percentage (BF%) and fat-free mass index assessed by air displacement plethysmography
C
Comparator
Lowest quartile of body fat percentage (BF%) and fat-free mass index
O
Outcome
Composite outcome of major adverse cardiovascular events (MACEs) including acute coronary syndromes, coronary revascularization, stroke, or death from any cause at median 3.9 years follow-upcomposite
In patients with coronary artery disease, higher body fat percentage is associated with increased cardiovascular risk, challenging the 'obesity paradox' often observed when using body mass index alone.
Cite This Study
Medina‐Inojosa et al. (2018) studied this question.