Why the study?
Does dofetilide affect potassium, sodium, and calcium currents in guinea pig cardiomyocytes?
Population
Guinea pig left ventricular cardiomyocytes
Comparison
Dofetilide at 10 M and higher concentrations vs Control currents (baseline/untreated state)
Design
Preclinical
Authors
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Supports dofetilide selectivity in guinea pig myocytes; leaves open translation to human arrhythmia therapy.
Does dofetilide affect potassium, sodium, and calcium currents in guinea pig cardiomyocytes?
Dofetilide is a highly selective blocker of the rapid delayed rectifier potassium current (IKr) and delays deactivation of the slow component (IKs) without affecting sodium or calcium currents.
Kiehn et al. (1994) studied this question.
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