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Parkinson's Disease (PD) is a progressive neurodegenerative disorder. Depression, a prevalent comorbidity across all stages, exacerbates PD severity. α-synuclein aggregation, the hallmark of PD, drives pathways overlapping with depression. This review places α-synuclein at the nexus of mechanistic synergy between PD and depression, and incorporates secondary analyses of genomic and transcriptomic datasets to identify convergent genes and pathways, underscoring depression's potential as a biomarker for diagnosis and progression of PD.
Yusuf et al. (Thu,) studied this question.
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