Why the study?
Does ART-naive HIV infection accelerate 96-week carotid intima media thickness progression compared to matched healthy controls?
Does ART-naive HIV infection accelerate 96-week carotid intima media thickness progression compared to matched healthy controls?
In ART-naive HIV-infected adults, 96-week CIMT progression is similar to healthy controls, but is independently predicted by traditional risk factors and hs-CRP.
Answers are grounded in this paper and cite their sources.
ART-naive HIV does not accelerate CIMT progression versus controls; leaves open hs-CRP as a predictor of vascular risk in this population.
: This is a 96-week prospective cohort study of antiretroviral therapy (ART)-naive HIV-infected adults and matched healthy controls to assess progression of carotid intima media thickness (CIMT) and its relationship to inflammation. Median common carotid artery (CCA) CIMT increased significantly but similarly in both groups [CCA: 0.02 (interquartile range: 0-0.05); P < 0.01 within HIV-infected adults vs. 0.01 (0-0.05) mm; P < 0.01 within controls; and P = 0.83 between groups]. Change in bulb CIMT yielded similar results. Independent predictors of CCA CIMT progression in HIV-infected adults were higher systolic blood pressure, total cholesterol, and high sensitivity C-reactive protein. Independent predictors of bulb CIMT progression were higher non-high-density lipoprotein cholesterol and high sensitivity C-reactive protein. Other inflammation markers were not associated with CIMT progression.
No takes yet. Share an insight, caveat, or question.
Hileman et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: